DINITROCHLOROBENZENE (DNCB)
TREATMENT INSTRUCTIONS

 

INITIAL DNCB APPLICATION (for people who have NEVER USED DNCB)

1. Using a cotton swab (such as a Q-tip), apply the 10% DNCB SOLUTION to the inner LEFT forearm in a 1" x 1" -square.

2. After a few minutes, apply the Q-tip with the 10% DNCB SOLUTION a second time on the same 1" x 1" -square location.

3. Let dry for a few minutes and cover with a large adhesive bandage, making certain that the adhesive part does not touch the application site. Do not remove bandage or wash the application site for at least eight hours.

4. Do not, under any conditions, apply DNCB again until two weeks has elapsed, even if there is no reaction at the application site.

5. If you have previously been sensitized to DNCB, start with the 2% DNCB SOLUTION instead of the 10% DNCB SOLUTION. The 10% DNCB SOLUTION should only be used by people who have never been sensitized to DNCB.

 

AFTER TWO WEEKS

1. Using a Q-tip, apply the 2% DNCB SOLUTION to the inner RIGHT forearm in a 1" x 1" -square.

2. After a few minutes, apply the Q-tip with the 2% DNCB SOLUTION a second time on the same 1" x 1" -square location.

3. Let dry for a few minutes and cover with a large adhesive bandage, making certain that the adhesive part does not touch the application site. Do not remove bandage or wash the application site for at least eight hours.

4. In less than seventy-two hours, the skin at the application site should be bright red, itchy, and slightly raised. If this happens, start weekly applications as per the next section.

5. If there is no reaction, continue with weekly applications of the 10% DNCB SOLUTION (alternating arms each week) until there is an appropriate response at the application site, then start weekly applications.

 

ONE WEEK LATER, AND EACH WEEK THEREAFTER

1. Repeat numbers 1 to 3 above using the 2% DNCB SOLUTION, using a different application site for each weekly application. Stinging at the site within one hour after application is a sign of an appropriate dose that will result in a good reaction, but this does not occur in all individuals.

2. It is mandatory to move the application site each week between the inner arms, inner thighs, and trunk (stomach, rib cage, and chest). It is especially important to apply DNCB on the upper and lower trunk areas twice as often as the other sites, since the lungs and gastrointestinal tract are primary sources of opportunistic infections. When applying to the trunk area, use a 2" x 2"- square. Every six weeks or more often if

there are infections, it is advisable to use extra DNCB by applying the Q-tip one additional time to the trunk area application site. To initiate an increased immune response, DNCB can be applied to more than one site during the weekly application (such as two trunk sites, arm and trunk, thigh and trunk, neck and trunk, etc.). It can also be applied at or near swollen lymph nodes.

3. If the application site is not bright red and slightly raised in twenty-four to seventy-two hours, the solution is too weak. For the next application, either increase the solution strength or apply one extra application with the Q-tip.

4. If the skin at the application site has raised blisters or open sores, decrease the strength of the application by either applying only once with the Q-tip, or using a weaker solution, such as 0.2% or 0.02%.

5. If the present application site becomes bright red in twenty-four to seventy-two hours or any previous application site changes color, you are considered sensitized and need only to continue applications on a weekly basis.

6. If severe contact dermatitis or itching occurs, apply calamine lotion, aloe vera , cocoa butter, or Bactine directly to the rash. The use of cortisone or hydrocortisone creams is not recommended, since they suppress the immune response to DNCB. An overly strong reaction resulting in dermatitis is a sign of an excellent immune response and is positive, not negative. The dermatitis will heal in time and will not leave a scar.

7. DNCB must be used weekly to be effective and to initiate appropriate systemic immune responses. However, DO NOT USE DNCB MORE THAN ONCE A WEEK, no matter what conditions or circumstances occur.

8. DNCB can be applied to Kaposi's sarcoma lesions at the same time as the weekly application. This may make the lesions turn yellow and fade.

 

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